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Sedating effect of antihistamine

This difference relates to the positioning and fit of the molecules in the histamine HThese compounds are structurally related to the ethylenediamines and the ethanolamines, and produce significant anticholinergic adverse effects.

Compounds from this group are often used for motion sickness, vertigo, nausea, and vomiting.

Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil.

Fexofenadine is associated with a decreased risk of cardiac arrhythmia compared to terfenadine.The isomerism is a significant factor in the activity of the agents in this group.E-triprolidine, for example, is 1000-fold more potent than Z-triprolidine.The second-generation H receptors and cholinergic receptors.This selectivity significantly reduces the occurrence of adverse drug reactions, such as sedation, while still providing effective relief of allergic conditions.

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